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Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling

✍ Scribed by Georges Romey; Luis Garcia; François Rieger; Michel Lazdunski

Book ID
117058249
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
423 KB
Volume
156
Category
Article
ISSN
0006-291X

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The alpha 1 subunit of the L-type Ca2+ channel plays a dual role in skeletal muscle. It is essential both for L-type Ca2+ channel activity and for the functioning of the voltage-sensor structure that is situated in the triads as a key element for excitation-contraction coupling. This paper shows, wi