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Targeting ubiquitin specific proteases for drug discovery

✍ Scribed by Laurent Daviet; Frédéric Colland


Book ID
116308851
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
722 KB
Volume
90
Category
Article
ISSN
0300-9084

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The post-translational modification of proteins with ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is an important signal in the regulation of a variety of biological processes. The attachment of either a single Ub, a 76 amino acid polypeptide, or multiple Ub entities helps to control the targeti