Histone deacetylase inhibitor FK228 inhi
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Ho Jeong Kwon; Myoung Sook Kim; Min Jung Kim; Hidenori Nakajima; Kyu-Won Kim
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Article
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2001
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John Wiley and Sons
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French
β 796 KB
## Abstract FK228 (formerly FR901228) was recently isolated from __Chromobacterium violaceum__ as a potent antitumor agent and its biologic target protein was identified as histone deacetylase (HDAC). Because of its unique chemical structure (__i.e.__, bicyclic depsipeptide) and activity profile in