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Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis

✍ Scribed by Urban, Daniel; Pöss, Janine; Böhm, Michael; Laufs, Ulrich

Book ID: 121298536
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 401 KB
Volume: 62
Category: Article
ISSN: 1558-3597
DOI: 10.1016/j.jacc.2013.07.056

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## Abstract LDL cholesterol (LDL‐C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low‐density lipoprotein cholesterol receptor (LDL‐R). LDL‐R is targeted for lysosomal degradation by association with proprotein convertase subtilisin‐kexin