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Targeting T cells to tumor cells using bispecific antibodies

โœ Scribed by Frankel, Stanley R; Baeuerle, Patrick A


Book ID
120287062
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
517 KB
Volume
17
Category
Article
ISSN
1367-5931

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High-affinity receptors expressed on the surface of some tumors can be exploited by chemically conjugating the ligand for the receptor and an antibody against immune effector cells, thus redirecting their cytolytic potential against the tumor. Ovarian carcinomas and some brain tumors express the hig