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Targeting Systemically Administered Proteins to Bone by Bisphosphonate Conjugation

โœ Scribed by Hasan Uludag; Jennifer Yang

Book ID
109386469
Publisher
American Institute of Chemical Engineers
Year
2002
Tongue
English
Weight
106 KB
Volume
18
Category
Article
ISSN
8756-7938

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A di(bisphosphonic acid) for protein cou
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โœ Geeti Bansal; Sรฉbastien A. Gittens; Hasan UludaฤŸ ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 252 KB

Proteins intended for treatment of bone diseases should ideally exhibit a high bone affinity, so that they are preferentially deposited to bones after systemic administration. This can be achieved by combining molecules having a high affinity to bone with the proteins. Bisphosphonates (BPs) are chem