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A Dendritic Tetra(bisphosphonic acid) for Improved Targeting of Proteins to Bone

✍ Scribed by Geeti Bansal; Jennifer E. I. Wright; Cezary Kucharski; Hasan Uludaǧ


Book ID
101530835
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
410 KB
Volume
117
Category
Article
ISSN
0044-8249

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A di(bisphosphonic acid) for protein cou
✍ Geeti Bansal; Sébastien A. Gittens; Hasan Uludağ 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB

Proteins intended for treatment of bone diseases should ideally exhibit a high bone affinity, so that they are preferentially deposited to bones after systemic administration. This can be achieved by combining molecules having a high affinity to bone with the proteins. Bisphosphonates (BPs) are chem