Targeting prostate cancer bone metastases
β Scribed by Christopher Logothetis; Shi-Ming Tu; Nora Navone
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 177 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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## Abstract Prostate cancer (CaP) is unique among all cancers in that when it metastasizes to bone, it typically forms osteoblastic lesions (characterized by increased bone production). CaP cells produce many factors, including Wnts that are implicated in tumorβinduced osteoblastic activity. In thi
## Abstract Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on radiographs. However, emerging evidence suggests that development o