Pathogenesis of osteoblastic bone metastases from prostate cancer
β Scribed by Toni Ibrahim; Emanuela Flamini; Laura Mercatali; Emanuele Sacanna; Patrizia Serra; Dino Amadori
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 263 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on radiographs. However, emerging evidence suggests that development o
## Abstract Prostate cancer (CaP) is unique among all cancers in that when it metastasizes to bone, it typically forms osteoblastic lesions (characterized by increased bone production). CaP cells produce many factors, including Wnts that are implicated in tumorβinduced osteoblastic activity. In thi
## Background: Certain solid tumors metastasize to bone and cause an osteoblastic response. the mechanisms by which tumor cells stimulate this new bone formation are not completely understood. ## Methods: The authors identified three breast cancer lines that cause osteoblastic metastases in femal