## Abstract Interphase fluorescence in situ hybridization (FISH) detects nonrandom cytogenetic abnormalities in plasma cell (PC) dyscrasia according to PC burden. However, when performed on cultured whole bone marrow (BM), it often fails to detect these aberrations. We have compared this interphase
β¦ LIBER β¦
Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype/genotype fluorescence in situ hybridization
β Scribed by Marilyn L. Slovak; Victoria Bedell; Kristen Pagel; Karen L. Chang; David Smith; George Somlo
- Book ID
- 113512662
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 420 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0165-4608
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## Abstract ## BACKGROUND Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell (PC) disorder usually characterized by a benign clinical course. However, in approximately 25% of patients, the disorder has been found to evolve into a multiple myeloma (MM). The mechanism
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