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Targeting of αv integrins interferes with FAK activation and smooth muscle cell migration and invasion

✍ Scribed by Jeeva Varadarajulu; Martin Laser; Markus Hupp; Rongxue Wu; Christof R. Hauck

Book ID
116290369
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
803 KB
Volume
331
Category
Article
ISSN
0006-291X

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## Abstract We previously showed that, while binding to urokinase receptor (uPAR) through its growth factor domain (GFD, residues 1–49), urokinase (uPA) can engage αvβ5 integrin through an internal domain (CP, residues 132–158). This novel uPA/αvβ5 interaction promotes cytoskeletal rearrangements a