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Use of RNA interference to inhibit integrin (α6β4)-mediated invasion and migration of breast carcinoma cells

✍ Scribed by Elizabeth A. Lipscomb; Aisling S. Dugan; Isaac Rabinovitz; Arthur M. Mercurio

Book ID
111553994
Publisher
Springer
Year
2003
Tongue
English
Weight
179 KB
Volume
20
Category
Article
ISSN
0262-0898

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## Abstract We previously showed that, while binding to urokinase receptor (uPAR) through its growth factor domain (GFD, residues 1–49), urokinase (uPA) can engage αvβ5 integrin through an internal domain (CP, residues 132–158). This novel uPA/αvβ5 interaction promotes cytoskeletal rearrangements a