Genetic engineering of human T lymphocytes to express tumor antigen-specific chimeric immune receptors is an attractive means for providing large numbers of effector cells for adoptive immunotherapy while bypassing major mechanisms of tumor escape from immune recognition. We have applied this strate
β¦ LIBER β¦
Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes
β Scribed by Constantin N. Baxevanis; Michael Papamichail
- Book ID
- 105966760
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 347 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional AP