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T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope

โœ Scribed by A Hombach; C Heuser; R Sircar; T Tillmann; V Diehl; W Kruis; C Pohl; H Abken


Book ID
119755793
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
341 KB
Volume
113
Category
Article
ISSN
0016-5085

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Genetic engineering of human T lymphocytes to express tumor antigen-specific chimeric immune receptors is an attractive means for providing large numbers of effector cells for adoptive immunotherapy while bypassing major mechanisms of tumor escape from immune recognition. We have applied this strate