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Targeting of the β2-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo

✍ Scribed by Markus Elfinger; Johannes Geiger; Günther Hasenpusch; Senta Üzgün; Nathalie Sieverling; Manish K. Aneja; Christof Maucksch; Carsten Rudolph

Book ID: 113692697
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 712 KB
Volume: 135
Category: Article
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2009.01.012

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## Abstract ## Background Current liposome‐based gene delivery methods for therapeutic benefit are limited by their low efficiency. One possible way to improve gene expression is to include a peptide with a nuclear localization signal (NLS) to enhance the movement of the transfection complex from