Background Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Methods Linear or branched polyethylenimine (PEI)/DNA complexes were generated
β¦ LIBER β¦
A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
β Scribed by Wiseman, J W; Goddard, C A; McLelland, D; Colledge, W H
- Book ID
- 110039349
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 203 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0969-7128
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## Abstract Lentivirus vectors are being investigated as gene delivery vehicles for cystic fibrosis airway gene therapy. Vesicular stomatitis virus G glycoprotein (VSVβG)βpseudotyped vectors transduce airway epithelia via receptors that are located predominantly on the basolateral surface of the ai