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Targeting Loss-of-Function Mutations in Tumor-Suppressor Genes as a Strategy for Development of Cancer Therapeutic Agents

โœ Scribed by Hong Wang; Haiyong Han; Spyro Mousses; Daniel D. Von Hoff

Book ID
114473960
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
310 KB
Volume
33
Category
Article
ISSN
0093-7754

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## Abstract Genes that are highly overexpressed in tumor cells can be required for tumor cell survival and have the potential to be selective therapeutic targets. In an attempt to identify such targets, we combined a functional genomics and a systems biology approach to assess the consequences of R