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Targeting liposomes with protein drugs to the blood–brain barrier in vitro

✍ Scribed by Corine C. Visser; Sanja Stevanović; L. Heleen Voorwinden; Louis van Bloois; Pieter J. Gaillard; Meindert Danhof; Daan J.A. Crommelin; Albertus G. de Boer

Book ID
113591490
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
144 KB
Volume
25
Category
Article
ISSN
0928-0987

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## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote