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Targeting Histone Deacetylase in Cancer Therapy

โœ Scribed by Hsiang-Yu Lin; Chang-Shi Chen; Shuan-Pei Lin; Jing-Ru Weng; Ching-Shih Chen


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

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A key event in the regulation of eukaryotic gene expression is the posttranslational modification of nucleosomal histones, which converts regions of chromosomes into transcriptionally active or inactive chromatin. The most well studied posttranslational modification of histones is the acetylation of