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Targeting ERK1/2 activation and proliferation in human primary schwannoma cells with MEK1/2 inhibitor AZD6244

✍ Scribed by Sylwia Ammoun; Natalia Ristic; Cordula Matthies; David A. Hilton; C. Oliver Hanemann


Book ID
113812407
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
828 KB
Volume
37
Category
Article
ISSN
0969-9961

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## Abstract Mutations in __KRAS__ or __BRAF__ frequently manifest in constitutive activation of the MEK1/2‐ERK1/2 signalling pathway. The MEK1/2‐selective inhibitor, AZD6244 (ARRY‐142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour cells can vary markedly in th