In mouse C3H 10T1/2 cells, we previously reported that TGF-beta1 first delays and later potentiates EGF-induced DNA synthesis corresponding to an inhibition of EGF-induced cyclin D1 expression at t = 13 h. We report here that in accord with DNA synthesis kinetics, TGF-beta1 initially suppresses EGF-
Association of decreased phosphorylation of ERK-2 with costimulation of rat T cell activation by MEK-1 inhibitors and TGF-β1
✍ Scribed by Åsa Schiött; Hans Olov Sjögren; Magnus Lindvall
- Book ID
- 108408080
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 582 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0165-2478
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Basic fibroblast growth factor (bFGF) and transforming growth factor‐β1 (TGF‐β1) play an important role in proliferation, differentiation, and survival of malignant gliomas and in normal glial cell biology. Because of these critical roles, potential interactions between these key growth
## Abstract Peroxisome proliferator‐activated receptors (PPAR) are novel nuclear receptors and PPARγ ligands have been shown to produce pro‐apoptotic effects in many cancer cell types, including colon cancer. PPARγ ligands exert their effect through PPARγ‐dependent (genomic) and PPARγ‐independent (