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Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver

✍ Scribed by Christian Ingo Schwer; Patrick Stoll; Urs Pietsch; Philipp Stein; Jessica Laqua; Ulrich Goebel; Alexander Hoetzel; Rene Schmidt


Book ID
116307980
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
827 KB
Volume
42
Category
Article
ISSN
1357-2725

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in