𝔖 Bobbio Scriptorium
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Targeting cancer with radiolabeled antibodies

✍ Scribed by David M. Goldenberg; Steven M. Larson; Ralph A. Reisfeld; Jeffrey Schlom

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
508 KB
Volume
16
Category
Article
ISSN
0167-5699

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Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-neg