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Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer’s Disease: Rationale and Current Status

✍ Scribed by Vallés, Ana Sofía; Borroni, María Virginia; Barrantes, Francisco J.


Book ID
126517209
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2014
Tongue
English
Weight
648 KB
Volume
28
Category
Article
ISSN
1172-7047

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## Abstract Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of dementia in the elderly associated with cholinergic dysfunction, including reductions in nicotinic acetylcholine receptors (nAChRs). In AD, astrocytes are implicated in the formation of senile plaques, one