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Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies

✍ Scribed by Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger…

Book ID: 120680143
Publisher: BioMed Central
Year: 2013
Tongue: English
Weight: 995 KB
Volume: 13
Category: Article
ISSN: 1471-2407
DOI: 10.1186/1471-2407-13-83

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Bispecific antibodies (bsAbs) directed to tumor-associated antigens and to receptors mediating T-cell activation, such as the TCR/CD3 complex and the co-stimulatory CD28 molecule, are capable of activating T cells at the surface of tumor cells, resulting in tumor-cell killing. Here we report the pre