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Targeting aggregation in the development of therapeutics for the treatment of Huntington’s disease and other polyglutamine repeat diseases

✍ Scribed by Steffan, Joan S; Thompson, Leslie Michels

Book ID
121303275
Publisher
Informa plc
Year
2003
Tongue
English
Weight
198 KB
Volume
7
Category
Article
ISSN
1472-8222

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CAG repeats resulting in long polyglutamine tracts have been implicated in the pathogenesis of at least eight neurodegenerative diseases including Huntington. Expression of polyglutamine repeats is required for disease and increasing length of the repeats leads to earlier onset of illness (anticipat