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Targeting activity of a TCR/IL-2 fusion protein against established tumors

โœ Scribed by Jinghai Wen; Xiaoyun Zhu; Bai Liu; Lijing You; Lin Kong; Hyung-il Lee; Kai-ping Han; Jeffrey L. Wong; Peter R. Rhode; Hing C. Wong

Book ID
105967425
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
710 KB
Volume
57
Category
Article
ISSN
0340-7004

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## Antibody -directed enzyme prodrug therapy (ADEPT) targets an enzyme selectively to a tumor where it converts a relatively non-toxic prodrug to a potent cytotoxic drug. Previous clinical work using antibody-enzyme chemical conjugates has been limited by the moderate efficiency of tumor targeting