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Targeting a Primary Trimolecular Complex for Type 1 Diabetes of NOD Mice

✍ Scribed by Li Zhang; Taylor Armstrong; Kelly Johnson; Brian Stadinski; George Eisenbarth

Book ID
113541675
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
44 KB
Volume
135
Category
Article
ISSN
1090-2341

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## Abstract ## Background Mutating the insulin B:9–23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I‐A$^{\rm{g7}}$‐insulin B:9–23 peptide‐TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9–23 peptide presented by I‐A$^