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Targeting a host process as an antiviral approach against dengue virus

✍ Scribed by Andrew C. Sayce; Joanna L. Miller; Nicole Zitzmann


Book ID
116917531
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
317 KB
Volume
18
Category
Article
ISSN
0966-842X

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Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the tr