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Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer's disease

✍ Scribed by Celeste Roney; Padmakar Kulkarni; Veera Arora; Peter Antich; Frederick Bonte; Aimei Wu; N.N. Mallikarjuana; Sanjeev Manohar; Hsiang-Fa Liang; Anandrao R. Kulkarni; Hsing-Wen Sung; Malladi Sairam; Tejraj M. Aminabhavi

Book ID: 113691020
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 940 KB
Volume: 108
Category: Article
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2005.07.024

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## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote