## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote
✦ LIBER ✦
Nanoparticle technology for delivery of drugs across the blood–brain barrier
✍ Scribed by Ulrike Schroeder; Petra Sommerfeld; Sven Ulrich; Bernhard A. Sabel
- Book ID
- 109389068
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 39 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The endothelial cell monolayer lining the vessel wall forms a size‐selective, semi‐permeable barrier between the blood and tissue that must be crossed by blood borne therapeutic agents to reach diseased extravascular tissue. Nanoparticles engineered to carry drugs present an opportunity