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Targeted mRNA Degradation by Deadenylation-Independent Decapping

✍ Scribed by Gwenael Badis; Cosmin Saveanu; Micheline Fromont-Racine; Alain Jacquier

Book ID: 116753572
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 561 KB
Volume: 15
Category: Article
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2004.06.028

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MicroRNAs (miRNAs) are ∼22 nucleotide RNAs that negatively regulate the expression of protein-coding genes. In a present model of miRNA function in animals, miRNAs that form imperfect duplexes with their targets inhibit protein expression without affecting mRNA levels. Here, we report that in C. ele