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Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

✍ Scribed by Shveta Bagga; John Bracht; Shaun Hunter; Katlin Massirer; Janette Holtz; Rachel Eachus; Amy E. Pasquinelli


Book ID
116352736
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
443 KB
Volume
122
Category
Article
ISSN
0092-8674

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Regulation by let-7 and lin-4 miRNAs Res
✍ Shveta Bagga; John Bracht; Shaun Hunter; Katlin Massirer; Janette Holtz; Rachel πŸ“‚ Article πŸ“… 2005 πŸ› Elsevier Science 🌐 English βš– 443 KB

MicroRNAs (miRNAs) are ∼22 nucleotide RNAs that negatively regulate the expression of protein-coding genes. In a present model of miRNA function in animals, miRNAs that form imperfect duplexes with their targets inhibit protein expression without affecting mRNA levels. Here, we report that in C. ele