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Targeted molecular dynamics simulation studies of calcium binding and conformational change in the C-terminal half of gelsolin

✍ Scribed by Hui Sun Lee; Robert Charles Robinson; Chul Hyun Joo; Heuiran Lee; Yoo Kyum Kim; Han Choe


Book ID
116292374
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
1009 KB
Volume
342
Category
Article
ISSN
0006-291X

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ