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Influence of the Environment in the Conformation of α-Helices Studied by Protein Database Search and Molecular Dynamics Simulations

✍ Scribed by Olivella, Mireia; Deupi, Xavier; Govaerts, Cedric; Pardo, Leonardo


Book ID
118515126
Publisher
Biophysical Society
Year
2002
Tongue
English
Weight
166 KB
Volume
82
Category
Article
ISSN
0006-3495

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ