Targeted inhibition of platelet-derived growth factor receptor-β subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats
✍ Scribed by Xie, W-F; Chen, S-W; Chen, Y-X; Zhang, X-R; Qian, H; Chen, W-Z
- Book ID
- 109855199
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 741 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0969-7128
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t
Abbreviations: HSC, hepatic stellate cells; ␣-SMA, ␣ smooth muscle actin; PDGF, platelet-derived growth factor; PPAR␥, peroxisome proliferator-activated receptor ␥; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-⌬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidi