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Targeted gene knockout mediated by triple helix forming oligonucleotides

✍ Scribed by Majumdar, Alokes; Khorlin, Alexander; Dyatkina, Natalia; Lin, F.-L. Michael; Powell, James; Liu, Jilan; Fei, Zhizhong; Khripine, Yuri; Watanabe, Kyoichi A.; George, Jay; Glazer, Peter M.; Seidman, Michael M.

Book ID: 109693900
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 69 KB
Volume: 20
Category: Article
ISSN: 1061-4036
DOI: 10.1038/2530

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## Abstract __Anthraquinone and pyrene analogues attached to the 3′ and/or 5′ termini of triplex‐forming oligonucleotides (TFOs) by various linkers increased the stability of parallel triple helices. The modifications are simple to synthesize and can be introduced during standard solid‐phase oligon