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Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

✍ Scribed by M. Talelli; M. Iman; C.J.F. Rijcken; C.F. van Nostrum; W.E. Hennink


Book ID
113693470
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
261 KB
Volume
148
Category
Article
ISSN
0168-3659

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Core-crosslinked polymeric micelles with
✍ Marina Talelli; Maryam Iman; Amir K. Varkouhi; Cristianne J.F. Rijcken; Raymond πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 486 KB

Doxorubicin (DOX) is clinically applied in cancer therapy, but its use is associated with dose limiting severe side effects. Core-crosslinked biodegradable polymeric micelles composed of poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate] (mPEG-b-p(HPMAm-Lac(n))) diblock copolym