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Targeted chemotherapy of endometrial, ovarian and breast cancers with cytotoxic analogs of luteinizing hormone-releasing hormone (LHRH)

✍ Scribed by Engel, J. B.; Schally, A. V.; Buchholz, S.; Seitz, S.; Emons, G.; Ortmann, O.

Book ID: 113039880
Publisher: Springer
Year: 2012
Tongue: English
Weight: 217 KB
Volume: 286
Category: Article
ISSN: 0003-9128
DOI: 10.1007/s00404-012-2335-1

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BACKGROUND. Receptors for luteinizing hormone-releasing hormone (LH-RH) are found in about 50% of human breast carcinomas. A highly potent cytotoxic agent, 2-pyrrolinodoxorubicin (AN-201), was linked to the agonist [D-Lys 6 ]LH-RH to form a cytotoxic LH-RH analog, AN-207, that can be targeted to LH-