Antitumor effects of the cytotoxic luteinizing hormone–releasing hormone analog AN-152 on human endometrial and ovarian cancers xenografted into nude mice
✍ Scribed by Carsten Gründker; Peter Völker; Frank Griesinger; Annette Ramaswamy; Attila Nagy; Andrew V. Schally; Günter Emons
- Book ID
- 114487880
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 94 KB
- Volume
- 187
- Category
- Article
- ISSN
- 1097-6868
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## Background: Receptors for luteinizing hormone-releasing hormone (lh-rh) found in prostate cancers might be used for targeting of chemotherapeutic agents. doxorubicin derivative 2-pyrrolinodoxorubicin (an-201) can be linked to carrier analog [d-lys6]lh-rh to form the targeted cytotoxic analog of
Experiments have been performed to clarify whether LHRH agonists might decrease growth of hormone-unresponsive prostate cancer in vivo. Male nude mice were injected s.c. with the human androgen-independent prostate tumor DU 145 cells; osmotic minipumps releasing the LHRH agonist Zoladex (LHRH-A) for