Targeted adenoviral gene transfer to the kidney
β Scribed by McDonald, Glenn A.
- Book ID
- 104474666
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 616 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0085-2538
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Background The a v integrin is present in vascular endothelium, including that of the kidney. It is also upregulated in the presence of inΒ―ammatory cytokines and in some neoplasms. In an effort to transduce vascular endothelial cells, we compare in vitro and in vivo adenoviral gene transfer of a vec
## Abstract ## Background One of the drawbacks of the currently available vectors for gene therapy is the lack of selectivity in gene delivery. We have therefore investigated a strategy to generate immunoliposomes to target nonβviral vectors to cell surface receptors on endothelium. ## Materials
## Abstract ## Background Gene delivery to the pulmonary circulation has been studied in adult animals, but has not been extensively investigated in neonates. ## Methods We tested the ability of recombinant, replicationβdefective adenovirus to transduce the pulmonary circulation when delivered b