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Retargeting adenoviral vectors to improve gene transfer into tumors

✍ Scribed by Hogg, R T; Thorpe, P; Gerard, R D


Book ID
109842770
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
790 KB
Volume
18
Category
Article
ISSN
0929-1903

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Background The a v integrin is present in vascular endothelium, including that of the kidney. It is also upregulated in the presence of inΒ―ammatory cytokines and in some neoplasms. In an effort to transduce vascular endothelial cells, we compare in vitro and in vivo adenoviral gene transfer of a vec