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TARDBP mutations in Parkinson's disease

✍ Scribed by Rayaprolu, Sruti; Fujioka, Shinsuke; Traynor, Sharleen; Soto-Ortolaza, Alexandra I.; Petrucelli, Leonard; Dickson, Dennis W.; Rademakers, Rosa; Boylan, Kevin B.; Graff-Radford, Neill R.; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ross, Owen A.


Book ID
120038492
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
147 KB
Volume
19
Category
Article
ISSN
1353-8020

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## Abstract TDP‐43 (TAR‐DNA binding protein) aggregates in neuronal inclusions in motoneuron disease (MND), as well as in frontotemporal lobar degeneration (FTLD) and FTLD associated with MND (FTLD‐MND). Mutations in __TARDBP__ gene, coding for TDP‐43, were found in patients with pure MND. We now d