## Abstract β‐Amino acids containing hybrid peptides and β‐peptides show great potential as peptidomimetics. In this paper we describe the synthesis and affinity toward the µ‐ and δ‐opioid receptors of β‐peptides, analogues of Leu‐enkephalin, deltorphin I, dermorphin and α,β‐hybrides, analogues of
✦ LIBER ✦
TAPP analogs containing β3-homo-amino acids: synthesis and receptor binding
✍ Scribed by D. Podwysocka; P. Kosson; A. W. Lipkowski; A. Olma
- Book ID
- 112180825
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 314 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.2433
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The synthesis and conformational properties of a series of dipeptide taste ligands, differing from the commercial sweetener aspartame by the presence of a methylene group between the C a and the C' carbon atoms (as in homo-b-residues) in either the L-Asp or the L-Phe residues, are described. Homo-b-