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Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells

✍ Scribed by Chao Tang; Hong-li Xue; Hai-bo Huang; Xiao-gang Wang


Book ID
116771997
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
481 KB
Volume
470
Category
Article
ISSN
0304-3940

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## Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells. LLL12 specifically inhibited STAT3 phosphorylation, nuclear localization, DNA binding activity, down‐regulated STAT3 downstream