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Tandem Ring-Closing Metathesis/Isomerization Reactions for the Total Synthesis of Violacein

✍ Scribed by Petersen, Mette T.; Nielsen, Thomas E.


Book ID
120186326
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
360 KB
Volume
15
Category
Article
ISSN
1523-7060

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Total synthesis of octalactin A via ring
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.