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Tandem michael reactions for the construction of pyrrolidine and piperidine ring systems

โœ Scribed by Achille Barco; Simonetta Benetti; Alberto Casolari; Gian Piero Pollini; Giampiero Spalluto

Book ID
104222253
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
234 KB
Volume
31
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A convergent one-pot construction of disubstituted pyrrolidine andpiperidinejiameworks has been accomplished through a simple protocol involving intermolecular conjugate addition of a nitrogen nucleophile to an electrophilic olejin followed by intramolecular trapping of the generated enolate by a built-in a&unsaturated acceptor.

๐Ÿ“œ SIMILAR VOLUMES

The Michael-alkylation ring synthesis: p
The Michael-alkylation ring synthesis: piperidine and pyrrolidine construction
โœ Joseph E. Dolfini; Dorothy M. Dolfini ๐Ÿ“‚ Article ๐Ÿ“… 1964 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 203 KB

The Mi&ael-alkylation sequence may be fundamentally visuallised as a two step process, involving a bifunctional molecule (I) contaking both mcleophilic and electrophilic groups and a typical polarized olefin molecule (II~A-CB,C~R,N~ etc.), taking place as followsr (I) (II) (III) The nucleophilic gro