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A one-pot synthesis of nitrohydroxylated pyrrolidine and piperidine ring systems by tandem Michael-Henry reaction

✍ Scribed by Achille Barco; Simonetta Benetti; Carmela De Risi; Gian P. Pollini; Romeo Romagnoli; Vinicio Zanirato


Book ID
103401144
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
240 KB
Volume
35
Category
Article
ISSN
0040-4039

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A convergent one-pot construction of disubstituted pyrrolidine andpiperidinejiameworks has been accomplished through a simple protocol involving intermolecular conjugate addition of a nitrogen nucleophile to an electrophilic olejin followed by intramolecular trapping of the generated enolate by a bu