Tandem hydroboration/reduction of trisubstituted β,γ-unsaturated esters for the asymmetric synthesis of chiral 1,3-diols
✍ Scribed by Fordred, Paul S.; Bull, Steven D.
- Book ID
- 123058667
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 850 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A tandem stereoselective reduction-olefination reaction of ethyl 2-acyl-2-fluoro-2-diethylphosphonoacetate employing NaBH 4 in EtOH was developed. The one-pot reaction gave a-fluoro-a,b-unsaturated esters with excellent (Z)-selectivity. A plausible mechanism involving a diastereoselective reduction
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