Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT1receptor antagonists
โ Scribed by Staples, Maree K. ;Grange, Rebecca L. ;Angus, James A. ;Ziogas, James ;Tan, Nichole P. H. ;Taylor, Michelle K. ;Schiesser, Carl H.
- Book ID
- 118207594
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 238 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1477-0520
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๐ SIMILAR VOLUMES
Ettlcient 1.2-asymmetric induction was realized in the addition ot a l-hydroxyalkyl radical (R2(7-OIt) to 3-hydroxy-l-(methylthio)-l-Cp-tolylsulfonyl)-l-alkenes and their acetates (1): Irradiationot l and benzophenone in an 'alcohol (R2CHOH) gave an adduct (2) with a high syn selectivity. Optically
Polymer bound olefins undergo free radical initiated 1,2-addition when reacted with a variety of haloalkanes. The strategy could be applied successfully to the solid-phase synthesis of dihaloethenylcyclopropane carboxylic acids which are the key fragments of synthetic pyrethroids.